Successful Treatment of Extensive Verrucous Epidermal Nevus with Combination Oral Acitretin and Topical 30% Urea Cream: A Literature Review & Case Report Study

Authors

  • Mohamed Mohsen Farhan Institute of Laser for Postgraduate Studies, University of Baghdad.
  • Samar Ahmed Jasim Department of dermatology, Al-Kindy College of Medicine, University of Baghdad, Baghdad, Iraq
  • Ethar Thaer Mustafa Department of Medicine, Al-Iraqia University / Collage of Medicine, Baghdad, Iraq.
  • Shaymaa Khalid Abdulqader Department of Radiology, Al-Kindy College of Medicine, University of Baghdad, Baghdad, Iraq
  • Nabeeha Najatee Akram Department of Paediatrics, Al-Mustansiriyah University, College of Medicine, Baghdad, Iraq.

DOI:

https://doi.org/10.58564/AIMCJ2.3.2025.230

Keywords:

Verrucous Epidermal Nevus, Acitretin, Urea Cream.

Abstract

Epidermal nevi (EN) are hamartomas that are characterized by hyperplasia of the epidermis and adnexal structures. This case report describes the successful treatment of extensive, long-standing Verrucous Epidermal Nevus (VEN) in a 15-year-old female using a combination oral Acitretin (25mg/day) and topical 30% Urea cream applied nightly. After failure of multiple prior therapies including topical agents and ablative CO2 laser, this regimen achieved a dramatic clinical and cosmetic response within 60 days, resulting in complete resolution of lesions with only mild cheilitis as a side effect.

Laboratory monitoring remained normal throughout treatment. This combination offers a promising non-surgical approach for extensive VEN.

 

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Published

2025-12-15

Issue

Vol. 2 No. 3 (2025): Al-Iraqia Medical College Journal (AIMCJ)

Section

Articles

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How to Cite

Successful Treatment of Extensive Verrucous Epidermal Nevus with Combination Oral Acitretin and Topical 30% Urea Cream: A Literature Review & Case Report Study. (2025). Al-Iraqia Medical College Journal, 2(3), 19-25. https://doi.org/10.58564/AIMCJ2.3.2025.230

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