Androgenic Marker as Indicators of Early Renal Impairment in Hypertensive patients

Abstract

Hypertension is a major cause of premature renal failure and is often associated with metabolic and hormonal abnormalities in men.

The growing body of evidence indicates that testosterone deficiency can increase renal susceptibility through mechanisms involving endothelial dysfunction. The purpose of the present study was to determine the association between total testosterone, free testosterone, sex hormone-binding globulin (SHBG), and early renal impairment in hypertensive men.

The study included 100 male patients diagnosed with essential hypertension (cases) and 60 male volunteers (control group). Participants were selected from internal medicine outpatient clinics at AL-Numan hospital; venous blood was centrifuged at 3000 rpm for 10 minutes to obtain serum.

Hypertensive individuals had significantly lower total testosterone (10.81 ± 2.92 nmol/L) and free testosterone levels (175.11 ± 48.24 pool/L), along with high levels of SHBG. These hormonal derangements were associated with a decrease in estimated Glomerular Filtration Rate (eGFR) and significant changes in Albumin-to-Creatinine Ratio (ACR), uric acid, and bicarbonate imbalances.

The current study shows significant differences in serum levels of androgenic markers between patients and controls. Quantitative analysis of serum parameters in hypertensive men found that free testosterone and SHBG showed a high correlation with renal dysfunction.