Evaluation of Interferon Gamma and Osteopontin levels in Relapsing- Remitting Multiple Sclerosis Patients

Abstract

Multiple sclerosis (MS) is a chronic neurological disorder. It is an autoimmune disorder, meaning that in MS the immune system which normally protects us from viruses, bacteria, and other threats mistakenly attacks healthy cells. predominantly affects young adults and is characterized by chronic autoimmune activity. This study explores the crucial role of cytokines, like interferon-gamma (IFN-γ) and Osteopontin which promoting inflammation and CNS tissue injury. The current study comprised fifty patients with relapse remitting MS. Blood was drawn from 50 MS patients and 40 healthy people who served as controls. The serum levels of IFN-γ and OPN were determined using an enzyme-linked immunosorbent assay (ELISA).

Our results indicate non-significant differences in IFN-γ level between MS patients and controls group of the study’s sample (P> 0.05), whereas the level OPN cytokines was significantly higher in patients with RRMS compared with healthy individuals (P≤ 0.001**).

The current study shown on significant differences between MS patients and controls in serum levels of IFN-γ. Higher OPN serum level in studied patients suggests that OPN increased in RRMS patients who were in remission phase.