Study the Relationship of Dynamic Thiol/Disulphide Homeostasis and Bone Turnover Markers in Postmenopausal Osteoporosis

Abstract

Osteoporosis is a skeletal disease differentiated by low bone density measured by dual-energy X-ray absorptiometry (DEXA). This study aimed to investigate the relationship between the levels of dynamic   thiol   and   the   procollagen   type   I N- terminal propeptide (PINP) in postmenopausal osteoporosis patients. The current study included a total number of 75 voluntaries  (Individuals) divided into two groups: the first was the control group of apparently healthy individuals. This group consisted of 22 samples whose ages ranged between (46-65 years). The second group was the group of patients of postmenopausal women with osteoporosis, which consisted of 53 samples whose ages also ranged between (46-65 years), The results of PINP, T-score, and Dynamic thiol showed significant variance between the studded groups (P<0.05). Serum levels of PINP showed a notable rise in osteoporosis patients compared to healthy individuals (P<0.01). Moreover, the serum level of Dynamic thiol showed a notable increase in the patient group when compared to the control group (p<0.05).Conclusion: according to the presented result PINP recommended indicator for bone turnover markers and a Dynamic thiol risk factors for fractures. Thiol /disulphide homeostasis shifted to the disulphide side.