Human Herpes Virus 6 Seroprevalence in pediatric leukemia: A case-control Study

Abstract

This study investigates the incidence of primary infections and reactivations of the HHV-6 virus in pediatric leukemia patients, and their possible role in the disease course or in contributing to immunosuppression. Human Herpesvirus 6 (HHV-6) Primary Infections and Reactivation in Children with Leukemia: A Clinical and Epidemiological Study” illustrates the gaps and problems in the research of HHV-6 viruses in children with leukemia which was the case in the United States and shows the defects in the use of clinics and hospital laboratories and the possible contribution of the systematic research of the pediatric oncology clinic in children suffering from leukemia aiming pediatric population of the country was the first step in Canadian leukemia and HHV-6 viruses in children. The present case-control study analyzed a total of blood samples. The case group comprised of children aged 1-13 years who were diagnosed with acute lymphoblastic leukemia (ALL) or acute myeloid leukemia (AML) with a sample size of 50. The control group had 50 children who were matched by age and sex with the case group and were healthy without any personal or familial history of hematological malignancies or viral illness. The collected samples were centrifuged and the sera were stored at 4 degrees Celsius till the analysis. hhv-6 specific IgG antibodies were assessed by the EL1SA technique. The mean serum level of HHV-6-specific IgG antibodies was significantly higher in the leukemia group (77.67 ± 21.79) compared to the control group (14.89 ± 2.93), and this difference was statistically significant (p < 0.001). Our findings indicate a higher prevalence of HHV-6 infection among pediatric leukemia patients. This may reflect viral reactivation due to immunosuppression rather than a direct oncogenic role for the virus.