Myeloperoxidase and Trace Elements Imbalance in Papillary Thyroid Carcinoma

Abstract

Certain trace elements, such as iron, zinc, magnesium, and copper, have been extensively studied for their impact on thyroid health. Imbalances or shortages of these elements can interfere with thyroid function and lead to thyroid-related issues.

This study aimed to evaluate imbalances in zinc, copper, iron, and magnesium and to assess relationships among trace elements, myeloperoxidase (MPO), and C-reactive protein (CRP) to understand their potential roles in patients with papillary thyroid cancer (PTC).

Thirty-four patients diagnosed with papillary thyroid cancer and thirty-one healthy individuals were enrolled in this study. Myeloperoxidase levels were determined using an ELISA kit, and CRP was measured using a Cobas c 311 automated analyzer from Roche Diagnostics. The determination of Zn, Cu, Mg, and Fe was performed using standard calibration curves for atomic absorption spectrophotometry. 

The results indicate that PTC patients exhibit elevated levels of MPO, C-RP, and Cu, whereas Zn, Fe, and Mg levels are diminished. These alterations could be associated with inflammation and deficiencies in trace elements. They may also reflect a connection among inflammatory processes, oxidative stress, and metabolic changes in the tumor microenvironment.

Nonetheless, this research did not establish the causal relationship between MPO and the trace elements, nor their clinical relevance. Additional studies are required to elucidate the underlying mechanisms and possible clinical implications of these results.